Study ERP001225 Download

AbstractThis project aims to determine the relationship between the physical properties and distribution of CGIs and relate this to DNA methylation, chromatin state and transcriptional competence.
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OrganismsMus musculus
DescriptionTissue-specific methylation patterns suggest a role for CpG island (CGI) methylation in differentiation and cell-type-specific gene regulation. We have applied CXXC affinity purification (CAP), MBD affinity purification (MAP) and chromatin immunoprecipitation (ChIP) in combination with solexa sequencing to investigate the extent and functional significance of CGI methylation in mouse sperm, blood, cerebellum and ES cells.
SubmitterThe Sanger Center
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